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Drug intolerance or drug sensitivity refers to an inability to tolerate the adverse effects of a medication, generally at therapeutic or subtherapeutic doses. Conversely, a patient is said to be "tolerating" a drug when they can tolerate its adverse effects.
For example, a person who developed an allergy to a red dye will be allergic to any new drug which contains that red dye. A drug allergy is different from an intolerance. A drug intolerance, which is often a milder, non-immune-mediated reaction, does not depend on prior exposure.
Hypersensitivity (also called hypersensitivity reaction or intolerance) is an abnormal physiological condition in which there is an undesirable and adverse immune response to antigen. It is an abnormality in the immune system that causes immune diseases including allergies and autoimmunity.
Drug tolerance or drug insensitivity is a pharmacological concept describing subjects' reduced reaction to a drug following its repeated use. Increasing its dosage may re-amplify the drug's effects; however, this may accelerate tolerance, further reducing the drug's effects.
Immunology, dermatology. Drug rash with eosinophilia and systemic symptoms or drug reaction with eosinophilia and systemic symptoms ( DRESS ), also termed drug-induced hypersensitivity syndrome ( DIHS ), is a rare reaction to certain medications. It involves primarily a widespread skin rash, fever, swollen lymph nodes, and characteristic blood ...
Symptoms of the allergy vary greatly between individuals and include rash, hives, nausea or vomiting, difficulty breathing, drop in blood pressure, dizziness or faintness, diarrhea, severe stomach pain, and possible anaphylaxis.
Multiple chemical sensitivity ( MCS ), also known as idiopathic environmental intolerances ( IEI ), is an unrecognized and controversial diagnosis characterized by chronic symptoms attributed to exposure to low levels of commonly used chemicals. [1] [2] Symptoms are typically vague and non-specific. They may include fatigue, headaches, nausea ...
Allergy and immunology: Symptoms: Itchy rash, throat swelling, numbness, shortness of breath, lightheadedness, low blood pressure: Usual onset: Over minutes to hours: Types: Anaphylactoid reaction, anaphylactic shock, biphasic anaphylaxis: Causes: Insect bites, foods, medications: Diagnostic method: Based on symptoms: Differential diagnosis
Signs and symptoms. Clinically, pseudoallergy and anaphylaxis are identical. [4] Pseudoallergy symptoms include gastrointestinal symptoms, urticaria, bronchospasm, and angioedema, [5] along with headache, edema, skin flushing, hypotension, and shock. [6]
NSAID (or nonsteroidal anti-inflammatory drug) hypersensitivity reactions encompass a broad range of allergic or allergic-like symptoms that occur within minutes to hours after ingesting aspirin or other NSAID nonsteroidal anti-inflammatory drugs. Hypersensitivity drug reactions differ from drug toxicity reactions in that drug toxicity ...