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Drug intolerance or drug sensitivity refers to an inability to tolerate the adverse effects of a medication, generally at therapeutic or subtherapeutic doses. Conversely, a patient is said to be "tolerating" a drug when they can tolerate its adverse effects.
Drug allergies or hypersensitivities can be broadly divided into two types: immediate reactions and delayed reactions. Immediate reactions take place within an hour of administration and are IgE mediated, while delayed reactions take place hours to weeks after administration and are T-cell mediated.
Hypersensitivity (also called hypersensitivity reaction or intolerance) is an abnormal physiological condition in which there is an undesirable and adverse immune response to antigen. [1] [2] It is an abnormality in the immune system that causes immune diseases including allergies and autoimmunity. It is caused by many types of particles and ...
While pseudoallergy and IgE-mediated allergy share some similarities in their clinical manifestations, pseudoallergy is not the same as common allergy or type 1 reactions. Pseudoallergy can be caused by a variety of medications through various pathways.
Type I hypersensitivity (or immediate hypersensitivity ), in the Gell and Coombs classification of allergic reactions, is an allergic reaction provoked by re-exposure to a specific type of antigen referred to as an allergen. [1] Type I is distinct from type II, type III and type IV hypersensitivities.
Type II hypersensitivity, in the Gell and Coombs classification of allergic reactions, is an antibody mediated process in which IgG and IgM antibodies are directed against antigens on cells (such as circulating red blood cells) or extracellular material (such as basement membrane).
Allergen immunotherapy, also known as desensitization or hypo-sensitization, is a medical treatment for environmental allergies, such as insect bites, and asthma. [1] [2] Immunotherapy involves exposing people to larger and larger amounts of allergens in an attempt to change the immune system's response.
In atopic individuals, non-parasitic antigens stimulate inappropriate IgE production, leading to type I hypersensitivity. [citation needed] Sensitivities vary widely from one person (or from one animal) to another. A very broad range of substances can be allergens to sensitive individuals.
Salicylate intolerance. Salicylic acid. Salicylate sensitivity is any adverse effect that occurs when a usual amount of salicylate is ingested. People with salicylate intolerance are unable to consume a normal amount of salicylate without adverse effects . Salicylate sensitivity differs from salicylism, which occurs when an individual takes an ...
Unlike the more common Type I allergies (e.g. hay fever), contact allergies are not mediated by histamine, making the use of normal allergy medication (antihistamine) medication ineffective and other drugs have to be used to treat the allergic reaction.