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Hypersensitivity (also called hypersensitivity reaction or intolerance) is an abnormal physiological condition in which there is an undesirable and adverse immune response to antigen. [1] [2] It is an abnormality in the immune system that causes immune diseases including allergies and autoimmunity .
Type I hypersensitivity (or immediate hypersensitivity ), in the Gell and Coombs classification of allergic reactions, is an allergic reaction provoked by re-exposure to a specific type of antigen referred to as an allergen. [1] Type I is distinct from type II, type III and type IV hypersensitivities.
This classification differs from the more prevalent Type I hypersensitivity (e.g., hay fever), where allergens bind to antibodies, that subsequently trigger mast cells. In contact allergies, the molecules responsible (allergens) are typically small and cannot be directly recognized by the immune system.
Allergies, also known as allergic diseases, are various conditions caused by hypersensitivity of the immune system to typically harmless substances in the environment. These diseases include hay fever, food allergies, atopic dermatitis, allergic asthma, and anaphylaxis.
Allergen. An allergen is a type of antigen that produces an abnormally vigorous immune response in which the immune system fights off a perceived threat that would otherwise be harmless to the body. Such reactions are called allergies . In technical terms, an allergen is an antigen that is capable of stimulating a type-I hypersensitivity ...
Type IV hypersensitivity, in the Gell and Coombs classification of allergic reactions, often called delayed-type hypersensitivity, is a type of hypersensitivity reaction that can take a day or more to develop. Unlike the other types, it is not humoral (not antibody-mediated) but rather is a type of cell-mediated response.
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